Plexins Promote Hedgehog Signaling Through Their Cytoplasmic GAP Activity
Justine M. Pinskey, Tyler M Hoard, Xiaofeng Zhao, Nicole E. Franks, Zoë C. Frank, Alexandra N. McMellen, Roman J. Giger, Benjamin L. Allen
This study identifies Plexins as novel components of the Hedgehog pathway, showing they promote signaling through their GAP activity and primary cilia interaction.
eLife · Sep 28, 2022Peer-reviewedDevelopmental Biology