Roman J. Giger

Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.

AxoMetric: A Rapid and Unbiased Tool for Automated Quantification of Axon Regeneration in Tissue Sections

AxoMetric quantifies axon regeneration in tissue sections with speed and accuracy, matching manual methods while enabling high-throughput analysis.

DSCAM preserves neuronal order during radial migration by antagonizing N-Cadherin adhesion and UNC5c repulsion

This study shows DSCAM maintains neuronal order during radial migration by inhibiting N-Cadherin adhesion and UNC5c repulsion, preserving migratory sequence in developing cortical neurons.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation

This study shows that Semaphorin receptors antagonize Wnt signaling by promoting beta-catenin degradation, independent of primary cilia.

The Injured Sciatic Nerve Atlas (iSNAT), Insights into the Cellular and Molecular Basis of Neural Tissue Degeneration and Regeneration

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

Plexins Promote Hedgehog Signaling Through Their Cytoplasmic GAP Activity

This study identifies Plexins as novel components of the Hedgehog pathway, showing they promote signaling through their GAP activity and primary cilia interaction.

THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

This study shows THAP1 regulates oligodendrocyte maturation by controlling lysosomal degradation of glycosaminoglycans in OPCs.

Analysis of the Immune Response to Sciatic Nerve Injury Identifies Efferocytosis as a Key Mechanism of Nerve Debridement

This study identifies efferocytosis as a key mechanism for nerve debridement following sciatic nerve injury through single-cell RNA-sequencing and genetic analysis.

RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling

The paper profiles nascent RNA in neuronal cultures to show activity-dependent transcriptional changes and links RAI1 to synaptic scaling mechanisms.

Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

This study shows that shRNAs cause microRNA dysregulation and global transcriptomic changes in neurons, independent of their target.

LRP1 Regulates Peroxisome Biogenesis and Cholesterol Homeostasis in Oligodendrocytes and is Required in CNS Myelin Development and Repair