Unusually Broad-spectrum small-molecule sensing using a single protein scaffold
Hao Tian, Jesús Beltrán, Wesley J. George, Chase Lenert-Mondou, Norman Seder, Zoe I. Davis, Samuel D. Swift, Thomas Girke, Timothy A. Whitehead, Ian R. Wheeldon, Sean R. Cutler
The paper identifies small-molecule sensors using ABA receptors and demonstrates their ability to detect diverse ligands including plant natural products and synthetic chemicals.
Proceedings of the National Academy of Sciences · Dec 15, 2025Peer-reviewedSynthetic Biology