Author

Chase Lenert-Mondou

University of California, Riverside

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:plant (other)· 2 Approach:statistical model· 2 Organism:yeast· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ian R. WheeldoniD· 4 shared Nicholas R. Robertson· 3 shared Sean R. CutleriD· 3 shared Timothy A. WhiteheadiD· 3 shared Alison C. LeonardiD· 2 shared Jesús BeltrániD· 2 shared Norman Seder· 2 shared Samuel D. SwiftiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersSynthetic Biology

Ian R. WheeldonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Computational design of dynamic biosensors for emerging synthetic opioids

Alison C. Leonard, Chase Lenert-Mondou, Rachel Chayer, Samuel D. Swift, Zachary T. Baumer, Ryan Delaney, Anika J. Friedman, Nicholas R. Robertson, Norman Seder, J.M. Wells, Lindsey M. Whitmore, Sean R. Cutler, Michael R. Shirts, Ian R. Wheeldon, Timothy A. Whitehead

The paper designs dynamic biosensors for detecting nitazenes and their metabolites using computational methods, achieving low nanomolar detection limits and limited cross-reactivity.

Nature Communications · Jan 7, 2026Peer-reviewedBiochemistry

Unusually Broad-spectrum small-molecule sensing using a single protein scaffold

Hao Tian, Jesús Beltrán, Wesley J. George, Chase Lenert-Mondou, Norman Seder, Zoe I. Davis, Samuel D. Swift, Thomas Girke, Timothy A. Whitehead, Ian R. Wheeldon, Sean R. Cutler

The paper identifies small-molecule sensors using ABA receptors and demonstrates their ability to detect diverse ligands including plant natural products and synthetic chemicals.

Proceedings of the National Academy of Sciences · Dec 15, 2025Peer-reviewedSynthetic Biology

PYR1 biosensor-driven genome-wide CRISPR screens for improved monoterpenoid production in Kluyveromyces marxianus

Nicholas R. Robertson, Chase Lenert-Mondou, Alison C. Leonard, Aida Tafrishi, Stephanie Carrera, Sang Cheon Lee, Yuna Aguilar, Leonardo Sanchez Zamora, Trinity Nguyen, Jesús Beltrán, Mengwan Li, Sean R. Cutler, Timothy A. Whitehead, Ian R. Wheeldon

The paper uses a PYR1 biosensor-driven CRISPR screen in Kluyveromyces marxianus to identify gene knockouts that enhance geraniol production by up to 2-fold.

bioRxiv · Nov 14, 2024 · PreprintSynthetic Biology

Optimized genome-wide CRISPR screening enables rapid engineering of growth-based phenotypes in Yarrowia lipolytica

Nicholas R. Robertson, Varun Trivedi, Brian Lupish, Adithya Ramesh, Yuna Aguilar, Anthony Arteaga, Alexander Nguyen, Sang Cheon Lee, Chase Lenert-Mondou, Marcus Harland‐Dunaway, Robert E. Jinkerson, Ian R. Wheeldon

The paper designs a high-activity CRISPR sgRNA library for Yarrowia lipolytica and uses it to identify genes involved in acetate and hydrocarbon tolerance.

bioRxiv · Jun 20, 2024 · PreprintSynthetic Biology