Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation.
Christopher J. Groten, Jasmine Kwan, Julia Groening, Maya Belleville, Nicholas Weilinger, Yanyang Bai, Stefan Wendt, Zoe Kortje, Faithful Olarinde, Isabelle Chung, Hyun B. Choi, Louise-Philippe Bernier, Ravi L. Rungta, Brian A. MacVicar
The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.
bioRxiv · Oct 24, 2026 · PreprintNeuroscience