Author

Stefan Wendt

University of British ColumbiaORCID 0000-0002-8754-2464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ada J. Lin· 2 shared Brian A. MacVicariD· 2 shared Christopher J. GroteniD· 2 shared Haakon B. NygaardiD· 2 shared Hyun B. ChoiiD· 2 shared Alice BuonfiglioliiD· 1 shared Brooke L. LatouriD· 1 shared Christopher Lee· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Ada J. Lin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation.

Christopher J. Groten, Jasmine Kwan, Julia Groening, Maya Belleville, Nicholas Weilinger, Yanyang Bai, Stefan Wendt, Zoe Kortje, Faithful Olarinde, Isabelle Chung, Hyun B. Choi, Louise-Philippe Bernier, Ravi L. Rungta, Brian A. MacVicar

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, , Haakon B. Nygaard

This paper uses a 3D human iPSC-derived neurosphere model to study how microglia modify cellular responses to chronic amyloidosis, revealing their role in reducing neurotoxicity and regulating AD-associated gene expression.

Journal of Neuroinflammation · Apr 24, 2025Peer-reviewedNeuroscience

A microglia-containing cerebral organoid model to study early life immune challenges

Alice Buonfiglioli, Raphael Kübler, Roy D. Missall, Renske de Jong, Stephanie Chan, Verena Claudia Haage, Stefan Wendt, Ada J. Lin, Daniele Mattei, Mara Graziani, Brooke L. Latour, Frederieke A. J. Gigase, Rebecca Chiu, Ya Zhang, Haakon B. Nygaard, , Lot D. de Witte

This paper introduces a cerebral organoid model with integrated microglia to study how inflammatory stimuli and microglial presence affect neurodevelopment and neurodevelopmental disorders.

bioRxiv · May 24, 2024Neuroscience