Author

Christopher J. Groten

University of British ColumbiaORCID 0000-0002-6063-7295Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Brian A. MacVicariD· 3 shared Hyun B. ChoiiD· 2 shared Stefan WendtiD· 2 shared Ada J. Lin· 1 shared Christopher Lee· 1 shared Da Young Kong· 1 shared David R. KaplaniD· 1 shared Declan J. Brennan· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Brian A. MacVicarORCID

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3 papers

Recent·Most cited

Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation.

Christopher J. Groten, Jasmine Kwan, Julia Groening, Maya Belleville, Nicholas Weilinger, Yanyang Bai, Stefan Wendt, Zoe Kortje, Faithful Olarinde, Isabelle Chung, Hyun B. Choi, Louise-Philippe Bernier, Ravi L. Rungta, Brian A. MacVicar

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, , Haakon B. Nygaard

This paper uses a 3D human iPSC-derived neurosphere model to study how microglia modify cellular responses to chronic amyloidosis, revealing their role in reducing neurotoxicity and regulating AD-associated gene expression.

Journal of Neuroinflammation · Apr 24, 2025Peer-reviewedNeuroscience

Quantitative fluorescence lifetime imaging uncovers a novel role for KCC2 chloride transport in dendritic microdomains

Nicholas L. Weilinger, Leigh E. Wicki‐Stordeur, Christopher J. Groten, Jeffrey M. LeDue, Kristopher Thomas Kahle, Brian A. MacVicar

The paper uses FLIM to map dendritic chloride ion levels and identifies KCC2's role in creating chloride microdomains, revealing implications for ischemic stroke.

Cell Reports · Oct 1, 2022Peer-reviewedNeuroscience