Brian A. MacVicar

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

The paper uses single-cell RNA-seq and spatial transcriptomics to identify and characterize distinct cell types at the murine brain interface, revealing their molecular features and potential interactions.

This paper uses a 3D human iPSC-derived neurosphere model to study how microglia modify cellular responses to chronic amyloidosis, revealing their role in reducing neurotoxicity and regulating AD-associated gene expression.

The paper uses FLIM to map dendritic chloride ion levels and identifies KCC2's role in creating chloride microdomains, revealing implications for ischemic stroke.

The paper shows that changes in external potassium concentration reciprocally regulate astrocyte free calcium levels through K-Cl cotransport mechanisms.

This study identifies Rap2 and TNIK as regulators of Plexin-dependent synaptic tiling in C. elegans, showing their role in restricting presynaptic assembly and forming tiled innervation.