Cholesterol-activated VapC12 toxin modulates growth and drug susceptibility in Mycobacterium tuberculosis
Zohra Hashmi, Shivendra Pratap Singh, Sakshi Talwar, Abhin Kumar Megta, Mitul Srivastava, Debapriyo Sarmadhikari, Prabhakar Babele, Sourabh Kundu, Taruna Sharma, Chandresh Sharma, Shailendra Asthana, Vengadesan Krishnan, Amit Kumar Pandey
This study identifies a cholesterol-binding motif in the VapC12 toxin of M. tuberculosis and shows that cholesterol activates the toxin, reducing bacterial growth and antibiotic susceptibility.
bioRxiv · Oct 10, 2025 · PreprintMicrobiology