MicrobiologybioRxivPreprint
Cholesterol-activated VapC12 toxin modulates growth and drug susceptibility in Mycobacterium tuberculosis
Zohra Hashmi, Shivendra Pratap Singh, Sakshi Talwar…·Amit Kumar Pandey
This study identifies a cholesterol-binding motif in the VapC12 toxin of M. tuberculosis and shows that cholesterol activates the toxin, reducing bacterial growth and antibiotic susceptibility.
DOI 10.1101/2025.10.10.681325