TUMOR HETEROGENEITY AND STEMNESS CAN BE SHAPED BY MECHANO-STRUCTURAL PARAMETERS IN OSTEOSARCOMA
Zunaira Shoaib, Aleczandria S. Tiffany, Kyle B. Timmer, Brendan A.C. Harley, Joseph Irudayaraj, Timothy M. Fan
This study shows that softer, anisotropic niches promote OS-CSC properties, including chemoresistance and tumorigenicity, through transcriptional and epigenetic changes.
bioRxiv · May 27, 2026 · PreprintCancer Biology