Joseph Irudayaraj

This study identifies novel 17β-hydroxysteroid dehydrogenases in Peptoniphilus and Anaerococcus that convert androstenedione to testosterone, expanding understanding of microbial androgen metabolism in the genitourinary tract.

This study shows that softer, anisotropic niches promote OS-CSC properties, including chemoresistance and tumorigenicity, through transcriptional and epigenetic changes.

The study identifies Actinobaculum massiliense as a urinary pathobiont capable of generating androgens via the dirAB pathway, using a novel HSDH assay.

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

This study evaluates the kidney toxicology of LiTFSI (HQ-115) in mice, finding biochemical changes, renal injuries, and epigenetic alterations linked to inflammation and cancer pathways.

This study examines PFAS exposure in firefighters through miRNA sequencing of plasma exosomes and compares results to general population data, finding no significant overall PFAS difference but miRNA expression heterogeneity.