TUMOR HETEROGENEITY AND STEMNESS CAN BE SHAPED BY MECHANO-STRUCTURAL PARAMETERS IN OSTEOSARCOMA
Zunaira Shoaib, Aleczandria S. Tiffany, Kyle B. Timmer…·Timothy M. Fan
This study shows that softer, anisotropic niches promote OS-CSC properties, including chemoresistance and tumorigenicity, through transcriptional and epigenetic changes.