Jongsu Choi

The paper generates a large-scale single-cell RNA-seq dataset of the mouse retina and integrates it with public data to create a comprehensive cell atlas.

This study identifies 16 pathogenic structural variants in 16 IRD families using whole-genome sequencing, finding SVs contribute 2.1% to unresolved IRD cases but less than SNVs and indels.

The paper performs spatial transcriptomic profiling of the mouse retina to uncover its laminar organization and generates a comprehensive spatial single cell reference atlas.

bindSC integrates single-cell multi-omics data accurately by aligning rows and columns without approximations, outperforming existing methods in various biological contexts.