Gustavo Rodríguez-Esteban

The paper identifies sampling artifacts in single-cell genomics and proposes solutions to mitigate them in cohort studies.

The paper uses single cell transcriptomics to show that transdifferentiation and reprogramming can be uncoupled in pre-B cells based on their intrinsic plasticity.

bigSCale is a scalable framework for analyzing large single-cell RNA sequencing datasets, showing improved speed and accuracy in differential expression analysis and identifying rare cell populations.