Amy Guillaumet-Adkins

Single-Nucleus Multi-Omic Atlas Maps Regulatory Architecture and Non-Coding Variant Effects across Adult Human Tissues

The paper constructs a single-nucleus multi-omic atlas of adult human tissues, identifying regulatory elements and variant effects across 21 tissues.

Altered immune and treatment response gene expression signatures among poverty-exposed children with B-ALL

This study identifies transcriptional signatures of steroid resistance and altered immune responses in poverty-exposed children with B-ALL using single-cell RNA sequencing.

Single cell expression analysis uncouples transdifferentiation and reprogramming

The paper uses single cell transcriptomics to show that transdifferentiation and reprogramming can be uncoupled in pre-B cells based on their intrinsic plasticity.

Comparison of single-cell whole-genome amplification strategies

This study compares six single-cell whole-genome amplification methods using human cells, finding that REPLIg performs best in DNA yield and uniformity while Ampli1 shows fewer technical artifacts.

bigSCale: An Analytical Framework for Big-Scale Single-Cell Data

bigSCale is a scalable framework for analyzing large single-cell RNA sequencing datasets, showing improved speed and accuracy in differential expression analysis and identifying rare cell populations.

matchSCore: Matching Single-Cell Phenotypes Across Tools and Experiments

matchSCore matches cell populations across tools, experiments, and technologies by comparing clustering and marker gene identification accuracy in simulated data and applying it to mouse and human cell atlas projects.

Single Cell Transcriptome Conservation in Cryopreserved Cells and Tissues

The paper demonstrates that a sample preservation method maintains single cell transcriptomes, allowing for transcriptomic analysis of cryopreserved cells without altering transcriptional profiles.