Bruno Di Stefano

The paper identifies ILF2/3 as a regulator of primate cell fate by suppressing Alu element editing, showing its role in preventing aberrant splicing and maintaining epigenetic stability.

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

The paper studies alternative splicing dynamics during mouse B cell reprogramming into iPS cells and identifies three RNA-binding proteins involved in splicing regulation.

The paper uses single cell transcriptomics to show that transdifferentiation and reprogramming can be uncoupled in pre-B cells based on their intrinsic plasticity.

The paper shows transcription factors drive genome topology changes before gene expression during cell reprogramming.