Thomas Graf

The paper investigates enhancer interactions in immune cell fate switching, finding synergistic and antagonistic effects of IRF8 and FOS enhancer pairs during transdifferentiation.

This study identifies SAM68 as a regulator of cardiomyocyte differentiation by enhancing Gata4 translation through RNA-binding in mouse embryonic stem cells.

The paper investigates β-catenin-dependent axial patterning in Nematostella and finds similar regulatory logic to deuterostomes, suggesting a common evolutionary origin.

The paper studies alternative splicing dynamics during mouse B cell reprogramming into iPS cells and identifies three RNA-binding proteins involved in splicing regulation.

The paper introduces TADdyn, a tool that simulates chromatin structural rearrangements during cell reprogramming using time-course 3C data and molecular dynamics, revealing a hit-and-stick mechanism for transcriptional stabilization.

The paper uses single cell transcriptomics to show that transdifferentiation and reprogramming can be uncoupled in pre-B cells based on their intrinsic plasticity.

OneD improves Hi-C reproducibility for samples with abnormal karyotypes by addressing copy number variations, outperforming existing methods while maintaining performance on normal karyotypes.

The paper shows transcription factors drive genome topology changes before gene expression during cell reprogramming.

The paper compares two Hi-C samples, showing how adherence to FAIR principles leads to successful sequencing projects.