Author

Sasha E. Larsen

Seattle Children's Research InstituteORCID 0000-0001-5034-9727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Rhea N. ColeriD· 3 shared Graham F. HatfulliD· 2 shared A.H. Diacon· 1 shared Andrew J. Fiore-GartlandiD· 1 shared Brittany D. Williams· 1 shared C.A. Guerrero Bustamante· 1 shared Carlos A. Guerrero-BustamanteiD· 1 shared Dominic SauvageauiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersMicrobiology

Rhea N. ColerORCID

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3 papers

Recent·Most cited

Activity of a three-phage combination against Mycobacterium tuberculosis in disease-relevant conditions

Saskia Janssen, Sasha E. Larsen, Marta Pozuelo Torres, M. Beldjenna, C.A. Guerrero Bustamante, I. Florian, T. Smytheman, Tingjie Guo, R.C. van Wijk, Graham F. Hatfull, A.H. Diacon, Rhea N. Coler, Jakko van Ingen

This study evaluates a three-phage combination's activity against Mycobacterium tuberculosis under hypoxic, acidic, and stationary-phase conditions, finding that phages require replicating bacteria for lytic activity.

bioRxiv · May 11, 2026 · PreprintMicrobiology

Comparative study on the virulence of mycobacteriophages

Ilaria Rubino, Carlos A. Guerrero-Bustamante, Melissa Harrison, Sheila Co, Isobel Tetreau, Mani Ordoubadi, Sasha E. Larsen, Rhea N. Coler, Reinhard Vehring, Graham F. Hatfull, Dominic Sauvageau

This study compares the virulence of three mycobacteriophages against Mycobacterium smegmatis under planktonic and early-stage biofilm conditions, finding that D29 and its cocktails show the highest virulence.

Journal of Virology · May 21, 2025Peer-reviewedMicrobiology

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew J. Fiore-Gartland, Rhea N. Coler

The paper evaluates human-derived tuberculosis disease risk biosignatures for their predictive fidelity across preclinical models and tissues using public datasets.

mSphere · Dec 9, 2024Peer-reviewedImmunology