Graham F. Hatfull

This study identifies host determinants for phage infection in Mycobacterium smegmatis using CRISPR interference, revealing receptor proteins and lipid components involved in phage entry.

The paper studies pharmacokinetics of mycobacteriophages in mice and develops a PBPK model to predict their distribution and clearance, showing that inhalation improves lung exposure.

This paper identifies gp48, a mycobacteriophage protein that inhibits the host enzyme Mpg, essential for cell wall biosynthesis, by disrupting its dimer formation.

This study identifies RyDEP as an enzyme that degrades 2'cADPR and 3'cADPR immune signals, inactivating bacterial defense and restoring NAD+.

This study evaluates a three-phage combination's activity against Mycobacterium tuberculosis under hypoxic, acidic, and stationary-phase conditions, finding that phages require replicating bacteria for lytic activity.

This study investigates the inactivating conditions of three mycobacteriophages used in compassionate-use NTM treatment to guide their development as therapeutics.

This study demonstrates that retron-mediated recombineering can be applied across multiple bacterial species, achieving high editing efficiencies in several phyla.

This study compares the virulence of three mycobacteriophages against Mycobacterium smegmatis under planktonic and early-stage biofilm conditions, finding that D29 and its cocktails show the highest virulence.

The paper identifies a novel capsid stabilization mechanism in bacteriophages that allows larger genomes to be packaged without changing capsid size, offering insights for gene delivery system engineering.

The paper reports the genome sequence of bacteriophage L, compares it to related phages, and identifies features related to restriction-modification systems in Salmonella.