Teruhisa Kato

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

This paper describes the discovery of S-892216, a potent SARS-CoV-2 3CLpro inhibitor with antiviral activity against multiple variants and low cross-resistance to existing drugs.

This study identifies antimalarials with novel mechanisms by comparing transcriptomic changes from drug perturbations in Plasmodium falciparum.

This paper introduces a high-throughput screening method to identify fast-killing antimalarial compounds by measuring parasite reduction ratio using Plasmodium falciparum lactate dehydrogenase and fluorescent probes.