Author

Kiyoshi Kita

Nagasaki UniversityORCID 0000-0002-0426-4308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:plant (other)· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 1

Frequent Co-Authors

D. K. InaokaiD· 3 shared Takaya SakuraiD· 3 shared Ryuta Ishii· 2 shared Teruhisa KatoiD· 2 shared Aiko Hattori· 1 shared Eizo TakashimaiD· 1 shared Endah Dwi HartutiiD· 1 shared Eri Yoshida· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

D. K. InaokaORCID

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3 papers

Recent·Most cited

Structural insights and mechanistic inhibition of Plasmodium falciparum dihydroorotate dehydrogenase by newly identified chemotypes

Japheth Kibet Ng'etich, Ryuta Ishii, Hina Yuasa, Ryo Hatanaka, Aiko Hattori, Jun-ichi Kishikawa, Endah Dwi Hartuti, Normalita Eka Pravitasari, Kiyoshi Kita, Yusuke Tateno, Teruhisa Kato, Takaya Sakura, T. Shiba, D.K. Inaoka

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

bioRxiv · Oct 26, 2026 · PreprintMicrobiology

Plasmodium falciparum diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesion

Minako Yoshida, Junpei Fukumoto, Shinya Miyazaki, Megumi Tanaka, Suzumi M. Tokuoka, Hideru Obinata, Takaya Sakura, Yoko Onizuka, D.K. Inaoka, Kiyoshi Kita, Kazuhide Yahata, Eizo Takashima, Hideo Shindou, Fuyuki Tokumasu

This study shows that PfDGAT is essential for Plasmodium falciparum survival by maintaining phospholipid homeostasis, regulating sexual differentiation, ER stress, and cytoadhesion.

bioRxiv · Oct 10, 2025 · PreprintMicrobiology

Accelerating antimalarial drug discovery with a new high-throughput screen for fast-killing compounds

Takaya Sakura, Ryuta Ishii, Eri Yoshida, Kiyoshi Kita, Teruhisa Kato, D. K. Inaoka

This paper introduces a high-throughput screening method to identify fast-killing antimalarial compounds by measuring parasite reduction ratio using Plasmodium falciparum lactate dehydrogenase and fluorescent probes.

ACS Infectious Diseases · Nov 19, 2024Peer-reviewedMicrobiology