Takaya Sakura

Structural insights and mechanistic inhibition of Plasmodium falciparum dihydroorotate dehydrogenase by newly identified chemotypes

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

Epigenetic landscape of the H3K27me3 mark in macrophages transformed by Theileria annulata

This study examines changes in the H3K27me3 epigenetic mark in Theileria annulata-transformed macrophages during attenuation, finding increased global H3K27me3 levels and broader genomic distribution without major transcriptional changes.

Plasmodium falciparum diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesion

This study shows that PfDGAT is essential for Plasmodium falciparum survival by maintaining phospholipid homeostasis, regulating sexual differentiation, ER stress, and cytoadhesion.

Efficient identification of antimalarials with novel mechanism of action via multi-sample transcriptomic profiling

This study identifies antimalarials with novel mechanisms by comparing transcriptomic changes from drug perturbations in Plasmodium falciparum.

Accelerating antimalarial drug discovery with a new high-throughput screen for fast-killing compounds

This paper introduces a high-throughput screening method to identify fast-killing antimalarial compounds by measuring parasite reduction ratio using Plasmodium falciparum lactate dehydrogenase and fluorescent probes.

Glycolytic enzymes form membrane-less condensates in the malaria parasite Plasmodium falciparum by sensing glucose levels

The paper identifies glycolytic enzyme condensates in Plasmodium falciparum under low glucose conditions, showing they form distinct structures without lipid membranes.