Valeriu Crudu

The paper identifies a rapidly expanding multidrug-resistant M. tuberculosis clade originating from Russia and circulating in Moldova, posing a threat to MDR-TB control.

This study examines immune cell differences in close contacts of TB patients based on QFT status, finding minimal differences among subgroups but clear immune changes in active TB patients.

This paper develops tiled amplicon sequencing panels for whole-genome sequencing of pathogenic bacteria without culturing, enabling drug resistance classification from clinical samples.

MixInfect2 accurately detects mixed Mycobacterium tuberculosis infections and estimates strain proportions, improving upon previous methods.

The paper evaluates short-read variant calling accuracy in Mycobacterium tuberculosis using Illumina and PacBio data, finding high precision with optimized mapping thresholds and identifying 68% of excluded repetitive regions as accurately called.

The paper introduces a transmission-based clustering method for identifying outbreak clusters using whole genome sequencing data, showing it outperforms SNP threshold methods in some scenarios.