Louis Grandjean

This paper develops tiled amplicon sequencing panels for whole-genome sequencing of pathogenic bacteria without culturing, enabling drug resistance classification from clinical samples.

MixInfect2 accurately detects mixed Mycobacterium tuberculosis infections and estimates strain proportions, improving upon previous methods.

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

The paper identifies pre-existing bedaquiline resistance variants in Mycobacterium tuberculosis genomes before clinical use of the drug, highlighting the need for rapid susceptibility testing.