Daisy Sproviero

The paper analyzes RNA-seq data from Parkinson's Disease patients and controls to find increased somatic mutations in PD, with some clonal mutations being protective.

This study investigates mitochondrial function in blood cells and dopamine neurons from Parkinson's disease patients, showing mitochondrial abnormalities and reversible alterations in some cell types.

The paper examines the association between clonal hematopoiesis and Parkinson's disease using whole exome sequencing data from controls and patients.

This study identifies 262 STRs significantly associated with MRI-derived grey matter volumes in UK Biobank participants, with 12 associations replicated and no nearby SNPs in linkage disequilibrium.

The paper compares RNA profiles in plasma-derived large and small extracellular vesicles from neurodegenerative disease patients and healthy controls, identifying disease-specific miRNA signatures.

This study shows that TDP-43 deficiency leads to R-loop accumulation and DNA damage, linking ALS pathology to R-loop homeostasis.