Andrés Aguilera

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

This study shows HDAC1 regulates DNA double-strand break repair by controlling γH2AX phosphorylation, highlighting a role for histone acetylation in DNA damage response.

The paper identifies RNA-binding proteins and mRNP assembly perturbations that lead to R-loop accumulation and DNA damage, linking these processes to cancer and neurodegenerative diseases.

This study shows SMARCAD1 resolves R-loops at replication forks, preventing genome instability and cancer mutations.

This study identifies H2A.Z as essential for efficient transcription-coupled NER and genome stability in UV-challenged yeast cells.

The paper identifies ZATT-mediated inhibition of TOP2B as a mechanism regulating estrogen-induced transcriptional changes through DNA supercoiling.

The paper identifies actin nucleators as essential for protecting replication forks by modulating RPA activity and preventing ssDNA degradation during replicative stress.

The paper shows that ADAR2-mediated RNA editing of DNA:RNA hybrids is essential for DNA double strand break repair by facilitating DNA end resection.

This study shows that TDP-43 deficiency leads to R-loop accumulation and DNA damage, linking ALS pathology to R-loop homeostasis.

The paper shows DNA:RNA hybrids form in cis during transcription and are recombinogenic without requiring Rad51.

The paper shows that Mus81 is essential for resolving recombination intermediates during replication restart in G2/M phase, independent of DNA supercoiling and crosslinks.