Interpretable deep learning for chromatin-informed inference of transcriptional programs driven by somatic alterations across cancers
Yifeng Tao, Xiaojun Ma, Drake Palmer…·Hatice U. Osmanbeyoglu
The paper introduces CITRUS, a deep learning model that infers transcriptional programs influenced by somatic alterations across 17 cancer types using genomic, transcriptomic, and epigenomic data from The Cancer Genome Atlas.