Tsukasa Ohmori

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

This study uses deep learning to show that V1b receptor knockout mice drink water faster after aquaresis, reducing osmolality and weight loss compared to wild-type mice.

This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

This paper develops engineered FVIII variants for hemophilia A gene therapy, showing improved secretion, coagulation activity, and efficacy at lower vector doses in mice and macaques.

This study uses base editing to create a universal FIX variant for hemophilia B treatment, increasing FIX activity in cell and mouse models.

This study shows that transient ATM inhibition improves knock-in efficiency in mouse hematopoietic stem cells by reducing DNA damage response and apoptosis.

This paper develops a single AAV vector system for liver-targeted gene knock-in therapy in mouse models of inherited liver diseases, achieving efficient therapeutic gene insertion without germline transmission.

This paper introduces a synthetic near-infrared luciferin, AkaSuke, that enhances deep-tissue bioluminescence imaging with firefly luciferases by improving detection sensitivity.

This study evaluates the efficacy and immunogenicity of the AAV.GT5 vector for hemophilia B gene therapy in pigs and macaques, finding improved transduction and reduced immunogenicity compared to AAV-Spark100.

This study shows that re-administering different AAV serotypes can overcome neutralizing antibody barriers in mice, enabling successful liver transduction with switched serotypes.