Takahiro Kuchimaru

Inflammasome activation drives gasdermin-independent plasma membrane rupture by clustering ninjurin-1 in macrophages

This study shows inflammasome activation causes necrotic cell death in macrophages without gasdermin D or E by clustering ninjurin-1, leading to plasma membrane rupture and IL-1β release.

Cell-autonomous thermogenesis of macrophage alters its antibacterial function

This study shows that macrophages generate heat through a cell-autonomous mechanism, which reduces their antibacterial function in cold environments.

The REFLEX system enables in vivo identification of perivascular angiogenic macrophages in the heart

The paper develops REFLEX and HUNTERuni-seq to identify perivascular angiogenic macrophages (PVAMs) that deliver VEGF-A to endothelial cells, showing physical contact is critical for effective signaling.

A bright synthetic near-infrared luciferin enhances the capabilities of deep-tissue bioluminescence imaging using firefly luciferases

This paper introduces a synthetic near-infrared luciferin, AkaSuke, that enhances deep-tissue bioluminescence imaging with firefly luciferases by improving detection sensitivity.