Deep learning enables feature extraction of 3D collagen architecture in cleared fibrotic tissues
Wout Houbart, Laura Schelfaut, Angeliki Vavladeli, Noah Borges, Marthe Boelens, Claudia M. Brenis Gomez, Bram Verstappe, Mohammad Ghiasloo, Nikita Vladimirov, Phillip Nicholas Blondeel, Charlotte L. Scott, Fabian F. Voigt, Bart N. Lambrecht, Fritjof Helmchen, Esther Hoste, , Thomas Naert
The paper develops a deep learning pipeline for analyzing 3D collagen architecture in cleared fibrotic tissues using optimized clearing, imaging, and a U-Net model.
bioRxiv · Feb 26, 2026 · PreprintCancer Biology