Kris Vleminckx

A CRISPR-based Xenopus tropicalis model for retroperitoneal liposarcoma with genetic control over the dedifferentiation process

This paper establishes a Xenopus tropicalis model of liposarcoma by perturbing p53 and Rb pathways, showing that pathway deregulation initiates tumors and that ep300 disruption promotes dedifferentiation.

Deep learning enables feature extraction of 3D collagen architecture in cleared fibrotic tissues

The paper develops a deep learning pipeline for analyzing 3D collagen architecture in cleared fibrotic tissues using optimized clearing, imaging, and a U-Net model.

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

The paper introduces Pythia, a tool that uses deep learning to predict CRISPR/Cas9 integration and editing outcomes by leveraging non-random DNA repair patterns.

Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

This study identifies cis-regulatory elements and non-coding variants associated with North Carolina macular dystrophy using multi-omics and enhancer assays.

ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia

This study identifies ΔN-Tp63 as a key mediator of Wnt/β-catenin signaling in basal stem cells of mucociliary epithelia, showing its role in inhibiting differentiation and promoting hyperplasia.

A new transgenic reporter line reveals Wnt-dependent Snail2 re-expression and cranial neural crest differentiation in Xenopus

This paper introduces a transgenic reporter line in Xenopus that reveals Snail2 re-expression and Wnt signaling activity during cranial neural crest differentiation.