Bart N. Lambrecht

The paper examines systemic immune changes across the CFTR dysfunction spectrum using single-cell immune profiling in pwCF, carriers, and non-carriers, revealing immune signatures linked to CFTR function.

This study identifies HIF-1α+ CD4 T cells as key coordinators of a tissue-resident immune network in the lung during infection and cancer.

The paper develops a deep learning pipeline for analyzing 3D collagen architecture in cleared fibrotic tissues using optimized clearing, imaging, and a U-Net model.

Continued allergen exposure drives lung TLO to generate ASCs that home to IL1-instructed para-bronchial cuffs.

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

This study uses a cell-specific hACE2 mouse model to investigate whether SARS-CoV-2 can directly infect endothelial cells, finding no evidence of productive infection or disease.

The paper develops a method to select optimal TCR transgenic clones using single-cell RNA sequencing and TCR repertoire analysis, enabling the generation of CORSET8 mice specific to SARS-CoV-2 Spike protein.

DALI is a software tool that integrates multimodal single-cell RNA-seq and immune receptor data to analyze T and B cell diversity, supporting both bioinformaticians and immunologists.

Unsupervised trajectory inference by SCORPIUS outperformed Wanderlust, Monocle and Waterfall across ten scRNA-seq datasets and predicted falling protein synthesis during dendritic cell development, validated in vivo.