Fabian F. Voigt

aDISCO: A clearing method to enable 3D microscopyof large archival paraffin-embedded human tissue blocks

aDISCO enables 3D microscopy of large archival FFPE human tissue blocks, revealing subtle pathologies in focal cortical dysplasia through deep-learning analysis.

A uniform tissue-clearing framework and mesoSPIM-ultra enable cm-scale single-neuron tracing

The paper introduces a tissue-clearing framework and mesoSPIM-ultra system for large-scale single-neuron tracing in cleared mouse tissue.

Altair-dvOPM: an open-access platform for large-field three-dimensional tissue imaging

Altair-dvOPM is an open-access microscope for large-field 3D tissue imaging, achieving micrometer resolution without custom objectives or specialized alignment.

Deep learning enables feature extraction of 3D collagen architecture in cleared fibrotic tissues

The paper develops a deep learning pipeline for analyzing 3D collagen architecture in cleared fibrotic tissues using optimized clearing, imaging, and a U-Net model.

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

The paper introduces Pythia, a tool that uses deep learning to predict CRISPR/Cas9 integration and editing outcomes by leveraging non-random DNA repair patterns.

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples

The paper introduces an improved open-source light-sheet microscope, mesoSPIM, with enhanced resolution, throughput, and compatibility with cleared samples.

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

The paper introduces a novel Schmidt objective for high-resolution imaging in cleared tissues, achieving high NA, long WD, and large FOV with only two optical elements.

Longitudinal quantitative whole-brain microscopy reveals distinct temporal and spatial efficacies of anti-Aβ therapies

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.

Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

The paper identifies a developmental transition in VIP+ and SST+ interneurons in the mouse barrel cortex around P14, where their responses to multi-whisker stimuli diverge and their thalamic inputs shift.

Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

The paper investigates how sensory input and behavior influence signal routing in the neocortex during short-term memory tasks in mice.

In-depth characterization of layer 5 output neurons of the primary somatosensory cortex innervating the mouse dorsal spinal cord

The paper identifies CCK+ S1-CST neurons as a major cortical input to the spinal dorsal horn and characterizes their synaptic connections and molecular diversity.

Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning

This study investigates how lateral orbitofrontal cortex neurons guide sensory circuits during reversal learning in mice through top-down signals and value prediction error.

Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer`s disease amyloidosis models

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

Context-dependent limb movement encoding in neuronal populations of motor cortex

This study shows that motor cortex neuronal populations encode limb movement differently based on environmental context, with M2 influencing this context-dependent encoding.

The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.