Lucía Spangenberg

The paper investigates genetic and behavioral factors influencing chronotype in an admixed Uruguayan population, identifying PER2 and BTRC as key genes associated with circadian rhythms.

This study identifies CSDC2 as an RBP critical for cardiomyocyte commitment during cardiac differentiation of hiPSCs, showing its loss impairs differentiation and its recovery rescues it.

This study analyzes genomic data from 52 individuals across the central Southern Cone to trace genetic ancestry and movements during the Middle to Late Holocene.

SiteCELL enables on-site purification and cryopreservation of PBMCs for immune single cell profiling, performing as well as Ficoll density gradient in both lab and rural settings.

PANCO reclassifies variants of uncertain significance in non-coding regions with high accuracy using integrated functional and evolutionary data.

The paper uses whole-genome sequencing to analyze indigenous ancestry in Uruguayans, identifying Amerindian genetic heritage and estimating admixture timing.

This study investigates the role of PUM1 and PUM2 in human ESCs, showing their involvement in maintaining pluripotency and enhancing cardiomyogenic differentiation.