Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: implications for prion diseases
Kalpshree Gogte, Fatemeh Mamashli, María Georgina Herrera…·Jörg Tatzelt
This study shows that membrane anchors prevent protein misfolding and aggregation by restricting conformational freedom, with implications for prion diseases.