Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: implications for prion diseases
Kalpshree Gogte, Fatemeh Mamashli, María Georgina Herrera, Simon Kriegler, Verian Bader, Janine Kamps, Prerna Grover, Roland Winter, Konstanze F. Winklhofer, Jörg Tatzelt
This study shows that membrane anchors prevent protein misfolding and aggregation by restricting conformational freedom, with implications for prion diseases.
Proceedings of the National Academy of Sciences · Dec 31, 2024Peer-reviewedMolecular Biology