Author

Eleanor K. O’Brien

Edith Cowan UniversityORCID 0000-0001-5145-7340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 1 Organism:human· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexey A. ShadriniD· 1 shared Anbupalam ThalamuthuiD· 1 shared Benjamin Grenier‐BoleyiD· 1 shared Christine Fennema‐NotestineiD· 1 shared Chun Chieh FaniD· 1 shared Colin Louis MastersiD· 1 shared Daniëlle PosthumaiD· 1 shared Ganna LeonenkoiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexey A. ShadrinORCID

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Author profile →

1 paper

Recent·Most cited

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

Jiahui Hou, Jonathan Hess, Nicola J. Armstrong, Joshua C. Bis, Benjamin Grenier‐Boley, Ida Karlsson, Ganna Leonenko, Katya T. Numbers, Eleanor K. O’Brien, Alexey A. Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A. Andreassen, Henry Brodaty, Margaret Gatz, , Stephen J. Glatt

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

Translational Psychiatry · Jul 25, 2022Peer-reviewedGenetic & Genomic Medicine