Nicola J. Armstrong

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Chromatin accessibility determines cell-type specific intron retention

The paper shows that chromatin accessibility influences cell-type specific intron retention and confirms intrinsic intron features affect splicing.

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

Causes of variation in epigenetic aging across the lifespan

This study investigates the causes of variation in DNA methylation age across the lifespan, finding that environmental factors, particularly shared ones, are the main drivers.

Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

This study examines the heritability and environmental influences on the plasma lipidome in older Australian twins, finding most variation is due to unique environmental factors.

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

The genetic architecture of the human cerebral cortex

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements

This study shows that replication timing influences epigenetic changes and chromosomal rearrangements in cancer by linking early and late replication to specific methylation and histone modifications.

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

An epigenome-wide association study of educational attainment (n = 10,767)

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.