Kaitlyn H. Hajdarovic

The paper analyzes single-nucleus multi-omics data from mouse hypothalamus to reveal sex-specific aging differences, particularly on the X chromosome.

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

This study uses single nuclei RNA-sequencing to identify cell-specific aging signatures in the hypothalamus of aged female mice, revealing Xist as a novel marker of neuronal aging in females.