Doudou Yu

Single-cell transcriptomic and epigenomic analysis reveals X-linked sex differences in aging mouse hypothalamus

The paper analyzes single-nucleus multi-omics data from mouse hypothalamus to reveal sex-specific aging differences, particularly on the X chromosome.

Cell type-resolved chromatin accessibility clocks for brain aging

The paper develops cell type-specific chromatin accessibility clocks using snATAC-seq data to predict age and detect aging-related changes in the brain.

scWeave: A deep learning model that bidirectionally translates between gene expression and chromatin structure at single cell resolution

scWeave translates between gene expression and chromatin structure at single-cell resolution using deep learning, improving cross-modality inference across multiple datasets.

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer's disease

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.