Habil Zare

This study shows that combining ACLY and OGDH inhibitors VPA and BA synergistically inhibits HCC cell lines with minimal toxicity to normal liver cells.

This study identifies strictly-selective drug targets for 13 cancers using higher-order synthetic lethal sets to minimize harm to non-tumor tissues.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

ZiPo is a deep neural network that de-noises scRNA-seq data by modeling dropouts and improving performance through a scale-invariant loss term.

The paper systematically analyzes genome-scale metabolic models of six microorganisms to identify multi-target drug candidates that selectively target specific organisms.

The paper integrates transcriptomic data with in-silico analyses to identify cellular, molecular, and causal pathways in trait and state depression.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.