Ashley E. Webb

Common and Sex-Biased Muscle Transcriptomic Aging Signatures Across Diverse Species

The paper identifies common and sex-biased aging biomarkers in skeletal muscle transcriptomes across six species, revealing shared and divergent molecular mechanisms of aging.

Sexual reproduction impacts vertebrate organ aging

This study shows that lifelong mating in killifish affects liver aging in a sex-specific manner and is associated with younger transcriptomic and proteomic ages in humans.

Single-cell transcriptomic and epigenomic analysis reveals X-linked sex differences in aging mouse hypothalamus

The paper analyzes single-nucleus multi-omics data from mouse hypothalamus to reveal sex-specific aging differences, particularly on the X chromosome.

Comparative Transcriptomic Analysis of Embryonic Stem Cells (ESCs) across Mammalian Species

This study compares transcriptomic profiles of embryonic stem cells across mammals, identifying conserved and species-specific pluripotency mechanisms and markers.

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer's disease

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

Sex-biased Transcriptome in in vitro Produced Bovine Early Embryos

This study identifies sex-biased gene expression, alternative splicing, and isoform dynamics in bovine embryos, linking male-biased metabolism to faster development and female-biased X-linked gene expression to sex-specific regulation.

Single-cell transcriptomics of peripheral blood in the aging mouse

This study uses single-cell RNA-sequencing to analyze aging mouse peripheral blood, identifying age-related changes in cell-type composition and transcriptional profiles.

Single cell analysis of the aging female hypothalamus

This study uses single nuclei RNA-sequencing to identify cell-specific aging signatures in the hypothalamus of aged female mice, revealing Xist as a novel marker of neuronal aging in females.

Differentiation drives widespread rewiring of the neural stem cell chaperone network

This study shows that neural stem cell differentiation rewires the chaperone network, reducing TRiC/CCT and increasing sHSPs, which shifts proteostasis strategy and may contribute to neurodegenerative disease susceptibility.

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation

The paper identifies chromatin accessibility differences between quiescent and activated neural stem cells, showing how these states regulate transcriptional changes during activation.