ImmunologybioRxivPreprint
Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
Adam Blaisdell, Stefanie Bachl, Luis R Sandoval…·Averil I. Ma
This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.
DOI 10.1101/2025.10.05.680562