Author

Luis R Sandoval

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander MarsoniD· 2 shared Carter ChingiD· 2 shared Julia C. CarnevaleiD· 2 shared Justin EyquemiD· 2 shared Adam BlaisdelliD· 1 shared Alan AshworthiD· 1 shared Ana Vasquez-Ibarra· 1 shared Averil I. MaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Alexander MarsonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

Hyuncheol Jung, Pascal Devant, Carter Ching, Mineto Ota, Emma Dann, Ronghui Zhu, Chandrima Modak, Ana Vasquez-Ibarra, Jennifer R. Hamilton, Zachary Steinhart, Wayne Ngo, Luis R Sandoval, Jae Hyung Jung, Jae Hyun J. Lee, Da Xu, , Julia C. Carnevale

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

Nature Biotechnology · Aug 17, 2026Peer-reviewedImmunology

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

Adam Blaisdell, Stefanie Bachl, Luis R Sandoval, Carter Ching, Christopher Bowman, Nupura Kale, Manu Prabandham, Morgan E. Diolaiti, Claire C. Havig, Rommel Advincula, Nika Lenci, Zhongmei Li, Emily Yamashita, Charlotte H. Wang, Shimin Zhang, , Averil I. Ma

This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.

bioRxiv · Oct 5, 2025 · PreprintImmunology