Tsung‐Heng Tsai

This paper quantifies histone acetylation turnover and acetyl-CoA sources in vivo using 2H2O labeling and mass spectrometry, showing diet-dependent changes in acetylation dynamics and substrate contributions.

This study integrates multi-omics data from alcohol-fed mice to reveal metabolic and epigenetic changes in early alcohol-associated liver disease, highlighting a shift toward antioxidant responses.

The paper introduces a statistical framework for detecting differential post-translational modification abundance in proteomics data, showing improved fold change estimation and detection compared to existing methods.