Paula Rodríguez‐Otero

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

This study engineers sdAb-based CAR T cells targeting BCMA, showing improved antitumor efficacy and persistence in multiple myeloma compared to existing therapies.

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.

The paper constructs a CAR-T cell functional atlas from over one million cells across 13 studies to link product composition with clinical response and identify sex- and age-dependent effects.