Luis‐Esteban Tamariz‐Amador

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma

This study engineers sdAb-based CAR T cells targeting BCMA, showing improved antitumor efficacy and persistence in multiple myeloma compared to existing therapies.

Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.

Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T products

The paper constructs a CAR-T cell functional atlas from over one million cells across 13 studies to link product composition with clinical response and identify sex- and age-dependent effects.

Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow

This study identifies novel RAB13+ endothelial and profibrotic mesenchymal cells in aged human bone marrow using single-cell RNA sequencing and spatial transcriptomics.