Molecular BiologybioRxivPreprint
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Se‐Hyung Park, Robert Nathaniel Helsley, Taghreed Fadhul…·Samir Softic
This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.