Christina D. King

The human ovary exhibits dynamic molecular remodeling in the decades post-menopause

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Acute LINE-1 overexpression rewires the transcriptome, proteome and secretome of primary human fibroblasts

This study shows that acute LINE-1 overexpression in human fibroblasts causes widespread changes in transcriptome, proteome, and secretome, affecting cell cycle and interferon pathways, beyond retrotransposition.

Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosis

The paper identifies distinct fibroblast and perivascular senescence subtypes in fibrosis using single-cell and spatial transcriptomics, showing their spatial organization and roles in fibrosis progression.

γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

Alzheimer's disease risk factor APOE4 exerts dimorphic effects on female bone

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

Shifts in protein aggregate stability define proteostasis decline in the aging human brain

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss

This study shows that tau oligomers cause progressive synapse dysfunction by initially weakening both presynaptic and postsynaptic components, followed by synaptic loss.

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

This study shows that overexpressing an Alu transposon in human fibroblasts causes widespread disruptions in aging-related pathways across transcriptome, proteome, and secretome.

Age-Dependent Increase and Dysregulation of the Splicing Machinery in Acute Myeloid Leukemia of Older Patients

This study identifies age-related dysregulation of the splicing machinery in older AML patients through proteomic analysis, highlighting potential targets for age-specific therapies.

Amyloid β accelerates age-related proteome-wide protein insolubility.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.

A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.